This ground-breaking collection introduces readers to the fascinating research field of political anthropology. The chapters engage in major theoretical and methodological debates to provide interpretive frames, analytical tools and ethnographic illustrations for culturally based interpretations of political phenomena, revealing the intersection between anthropology, culture, politics and international relations. Theoretical tools such as liminality, sacrifice, mimesis, ethics, trickster and interpretation of meaning provide understanding of key challenges in a globalised world. These include war zones, revolutions, migration, securitization, territorial borders, climate change and ethno-religious violence. The contributing authors focus on the ethnographies of power, political culture and forms of cultural intimacy in informal networks. Using self-critical and reflexive approaches, they show that disciplinary boundaries have been reshaped by changing meanings of power, including reconfigurations of state and sovereignty. With reflections on the potential and limits of political anthropology, this Handbook explores the art of understanding human interaction within political frameworks in a globalising world. Offering a unique reference resource in the area with exceptional cross-disciplinary research, this Handbook will suit political, social and cultural anthropologists as well as scholars in comparative political analysis and social theory. Students and researchers of politics, anthropology and international relations will also benefit from the key methodological tools explaining the challenges and consequences of globalisation.